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1 December 2001 DISPOSITION OF SULFADIMETHOXINE IN CAMELS (CAMELUS DROMEDARIUS) FOLLOWING SINGLE INTRAVENOUS AND ORAL DOSES
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Abstract

Single-dose pharmacokinetics of sulfadimethoxine were determined in six adult camels (Camelus dromedarius) following administration of a mean dosage of 17.5 ± 2.7 mg/kg both i.v. and p.o. Serial blood samples were collected through an indwelling jugular catheter intermittently for 5 days for both routes. Sulfadimethoxine was assayed using high-performance liquid chromatography. Serum drug concentration versus time data for each animal was subjected to linear regression, with the best-fit model selected based on residual analysis. The data fit best into a two-compartment open model, with first-order input for oral administration. For orally administered drug, mean maximum serum concentration of 19.3 ± 1.7 μg/ml was reached at 11.41 ± 2.59 hr, with an elimination rate constant of 0.09/hr ± 0.05/hr and an elimination half-life of 11.7 ± 3 hr. Mean peak serum concentration following i.v. administration was 223 ± 48 μg/ml. Mean volume of distribution at steady state was 0.393 ± 0.049 L/kg. Elimination rate constants differed with i.v. and oral administration, suggesting a flip-flop model. Oral bioavailability was 103% ± 38%. Comparison of maximum serum concentrations to the microbial breakpoint concentration reported for sulfadimethoxine (512 μg/ml) suggests that the dose used in this study, 17.5 ± 2.7 mg/kg, is insufficient for achieving therapeutic serum levels.

Jenifer Chatfield, James Jensen, Dawn Boothe, Tanya Herzog, and Katherine Junkins "DISPOSITION OF SULFADIMETHOXINE IN CAMELS (CAMELUS DROMEDARIUS) FOLLOWING SINGLE INTRAVENOUS AND ORAL DOSES," Journal of Zoo and Wildlife Medicine 32(4), 430-435, (1 December 2001). https://doi.org/10.1638/1042-7260(2001)032[0430:DOSICC]2.0.CO;2
Received: 29 March 2001; Published: 1 December 2001
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