Translator Disclaimer
1 September 2002 MORTALITY ASSOCIATED WITH MELARSOMINE DIHYDROCHLORIDE ADMINISTRATION IN TWO NORTH AMERICAN RIVER OTTERS (LONTRA CANADENSIS) AND A RED PANDA (AILURUS FULGENS FULGENS)
Author Affiliations +
Abstract

Two adult North American river otters (Lontra canadensis) and an adult red panda (Ailurus fulgens fulgens) at three separate institutions died within 22 hr after receiving single 2.5- to 2.7-mg/kg doses of melarsomine dihydrochloride administered in the epaxial musculature as a treatment for filarid nematodes. One otter had a suspected Dirofilaria immitis infection, the other had a confirmed D. lutrae infection, and the red panda had a confirmed Dirofilaria sp. infection, presumably with D. immitis. Postmortem examinations revealed similar gross lesions, although they were less severe in the red panda. The trachea and primary bronchi contained abundant foamy fluid, the lungs were mottled with areas of consolidation, and the pulmonary parenchyma exuded abundant fluid at the cut section. Histologic evaluation revealed acute pulmonary edema, which resulted in respiratory failure and death. There may have been direct pulmonary cellular toxicity of melarsomine dihydrochloride or a severe systemic anaphylactic reaction to antigens released after parasite death. An idiosyncratic drug reaction or a low therapeutic index of melarsomine probably caused the death of the three individuals. Melarsomine dihydrochloride use should be avoided in North American river otters and red pandas.

Donald L. Neiffer, Edwin C. Klein, Paul P. Calle, Michael Linn, Scott P. Terrell, Rodney L. Walker, Donna Todd, Carol C. Vice, and Steven K. Marks "MORTALITY ASSOCIATED WITH MELARSOMINE DIHYDROCHLORIDE ADMINISTRATION IN TWO NORTH AMERICAN RIVER OTTERS (LONTRA CANADENSIS) AND A RED PANDA (AILURUS FULGENS FULGENS)," Journal of Zoo and Wildlife Medicine 33(3), (1 September 2002). https://doi.org/10.1638/1042-7260(2002)033[0242:MAWMDA]2.0.CO;2
Received: 15 September 2000; Published: 1 September 2002
JOURNAL ARTICLE
7 PAGES


SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top