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1 June 2006 PHARMACOKINETICS OF FLORFENICOL AFTER A SINGLE INTRAMUSCULAR DOSE IN WHITE-SPOTTED BAMBOO SHARKS (CHILOSCYLLIUM PLAGIOSUM)
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Abstract

This study evaluated the pharmacokinetics of florfenicol in the white-spotted bamboo shark (Chiloscyllium plagiosum). In addition to the pharmacokinetics, the potential application for treatment of bacterial meningitis was explored. A pilot study was used to compare doses of 30, 40, and 50 mg/kg i.m. Following that study, 10 adult sharks were administered a single i.m. dose of florfenicol at 40 mg/kg. Plasma and cerebrospinal fluid were collected and analyzed for florfenicol by a sensitive and specific high-pressure liquid chromatographic method. Pharmacokinetic analysis was performed using both non-compartmental and compartmental techniques. The absorption produced an average peak at 54 (±19) hr from the i.m. site of administration, and the half-life was prolonged, averaging 269.79 hr (±135.87). Florfenicol plasma concentrations peaked at an average of 11.85 μg/ml (±1.45) and were maintained above our target minimum inhibitory concentration of 4–8 μg/ml for at least 120 hr. Cerebrospinal fluid concentrations peaked at an estimated 9 μg/ml around 48 hr, surpassing the target minimum inhibitory concentration for at least 72 hr.

Dawn M. Zimmerman, Douglas L. Armstrong, Thomas G. Curro, Sarah M. Dankoff, Kathleen W. Vires, Kimberly K. Cook, Nathan D. Jaros, and Mark G. Papich "PHARMACOKINETICS OF FLORFENICOL AFTER A SINGLE INTRAMUSCULAR DOSE IN WHITE-SPOTTED BAMBOO SHARKS (CHILOSCYLLIUM PLAGIOSUM)," Journal of Zoo and Wildlife Medicine 37(2), 165-173, (1 June 2006). https://doi.org/10.1638/05-065.1
Received: 5 July 2005; Published: 1 June 2006
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