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1 June 2006 PAPILLOMAVIRUS-ASSOCIATED BASOSQUAMOUS CARCINOMA IN AN EGYPTIAN FRUIT BAT (ROUSETTUS AEGYPTIACUS)
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Abstract

A 5-yr-old female Egyptian fruit bat (Rousettus aegyptiacus) had a small raised pigmented mass removed from the lateral canthus of the left eye. Six additional variably sized, raised, smooth to cauliflower-like skin masses were observed randomly distributed throughout the left wing membranes. Four masses were removed and diagnosed microscopically as basosquamous carcinomas and papillomas. Additional masses, removed 6 mo and 1 yr later, showed bony invasion and squamous differentiation. Immunohistochemistry detected positive intranuclear staining for bovine papillomavirus antibody in all samples. Polymerase chain reaction done on DNA extracts from formalin-fixed, paraffin-embedded tumor tissue amplified a 450 base-pair segment analogous to the L1 region of human papillomavirus types 96 and 5. Basic Local Alignment Search Tool analysis of sequenced amplicons suggests a novel chiropteran papillomavirus. To our knowledge, this is the first report of papillomavirus-associated carcinoma in a chiropteran species.

Christy A. McKnight, Annabel G. Wise, Roger K. Maes, Christopher Howe, Annabel Rector, Marc Van Ranst, and Matti Kiupel "PAPILLOMAVIRUS-ASSOCIATED BASOSQUAMOUS CARCINOMA IN AN EGYPTIAN FRUIT BAT (ROUSETTUS AEGYPTIACUS)," Journal of Zoo and Wildlife Medicine 37(2), 193-196, (1 June 2006). https://doi.org/10.1638/05-101.1
Received: 28 September 2005; Published: 1 June 2006
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