The nonsteroidal antiinflammatory drug ketoprofen (KTP) is a commonly used antiinflammatory and analgesic agent in reptile medicine, but no studies documenting its pharmacokinetics in this species have been published. Ketoprofen was administered as a racemic mixture to green iguanas (Iguana iguana) intravenously (i.v.) and intramuscularly (i.m.) at 2 mg/kg. Pharmacokinetic analyses were performed and indicated that ketoprofen in iguanas administered by the intravenous route has a classical two-compartmental distribution pattern, a slow clearance (67 ml/ kg/hr) and a long terminal half-life (31 hr) compared to ketoprofen studies reported in mammals. When delivered by the intramuscular route, bioavailability was 78%. These data indicate the daily dosing that is generally recommended for reptile patients, as an extrapolation from mammalian data, may be more frequent than necessary.
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1 December 2006
PHARMACOKINETICS OF KETOPROFEN IN THE GREEN IGUANA (IGUANA IGUANA) FOLLOWING SINGLE INTRAVENOUS AND INTRAMUSCULAR INJECTIONS
Allison D. Tuttle,
Mark Papich,
Gregory A. Lewbart,
Shane Christian,
Conny Gunkel,
Craig A. Harms
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Journal of Zoo and Wildlife Medicine
Vol. 37 • No. 4
December 2006
Vol. 37 • No. 4
December 2006
analgesia
green iguana (Iguana iguana)
ketoprofen
NSAID
pharmacokinetics
reptile