Translator Disclaimer
1 December 2006 PHARMACOKINETICS OF KETOPROFEN IN THE GREEN IGUANA (IGUANA IGUANA) FOLLOWING SINGLE INTRAVENOUS AND INTRAMUSCULAR INJECTIONS
Author Affiliations +
Abstract

The nonsteroidal antiinflammatory drug ketoprofen (KTP) is a commonly used antiinflammatory and analgesic agent in reptile medicine, but no studies documenting its pharmacokinetics in this species have been published. Ketoprofen was administered as a racemic mixture to green iguanas (Iguana iguana) intravenously (i.v.) and intramuscularly (i.m.) at 2 mg/kg. Pharmacokinetic analyses were performed and indicated that ketoprofen in iguanas administered by the intravenous route has a classical two-compartmental distribution pattern, a slow clearance (67 ml/ kg/hr) and a long terminal half-life (31 hr) compared to ketoprofen studies reported in mammals. When delivered by the intramuscular route, bioavailability was 78%. These data indicate the daily dosing that is generally recommended for reptile patients, as an extrapolation from mammalian data, may be more frequent than necessary.

Allison D. Tuttle, Mark Papich, Gregory A. Lewbart, Shane Christian, Conny Gunkel, and Craig A. Harms "PHARMACOKINETICS OF KETOPROFEN IN THE GREEN IGUANA (IGUANA IGUANA) FOLLOWING SINGLE INTRAVENOUS AND INTRAMUSCULAR INJECTIONS," Journal of Zoo and Wildlife Medicine 37(4), 567-570, (1 December 2006). https://doi.org/10.1638/06-029.1
Received: 29 March 2006; Published: 1 December 2006
JOURNAL ARTICLE
4 PAGES


SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top