This report describes the gross, histologic, and immunohistochemical features of ovarian dysgerminomas in two adult female mountain chicken frogs (Leptodactylus fallax) from the same zoological institution. One frog was found dead, and the other frog had been ill for several days with a bloated abdomen and lethargy. On necropsy, large, pale multilobulated masses replaced the left ovary in both frogs, and one frog also had numerous smaller nodules scattered throughout the coelomic viscera. Histologically, these masses were composed of sheets and cords of polyhedral discrete germ cells consistent with the diagnosis of dysgerminoma. Neoplastic cells stained positive with immunohistochemistry for Oct4, which has been reported to detect stem cells including germ cells in a variety of species, including humans. Ovarian tumors are uncommonly encountered in both reptiles and amphibians, and this report is the first report of dysgerminoma in any amphibian species.
How to translate text using browser tools
1 March 2007
OVARIAN DYSGERMINOMAS IN TWO MOUNTAIN CHICKEN FROGS (LEPTODACTYLUS FALLAX)
Scott D. Fitzgerald,
Ann E. Duncan,
Chris Tabaka,
Michael M. Garner,
April Dieter,
Matti Kiupel
ACCESS THE FULL ARTICLE
Journal of Zoo and Wildlife Medicine
Vol. 38 • No. 1
March 2007
Vol. 38 • No. 1
March 2007
dysgerminoma
Leptodactylus fallax
mountain chicken frog
neoplasia
ovary