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1 September 2007 DIAGNOSIS AND TREATMENT OF CHRONIC T-LYMPHOCYTIC LEUKEMIA IN A SPOTTED HYENA (CROCUTA CROCUTA)
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Abstract

Physical examination of an asymptomatic 20-yr-old intact female spotted hyena (Crocuta crocuta) revealed a midabdominal mass. A complete blood count (CBC) revealed peripheral lymphocytosis. Abdominal ultrasonography and laparoscopy confirmed severe splenomegaly. Cytologic examination of a bone-marrow core and histologic examination of spleen and liver biopsy samples revealed neoplastic small lymphocytes. Immunohistochemical staining of liver and spleen samples with the use of leukocyte-specific monoclonal antibodies showed that the neoplastic lymphocytes were immunoreactive to T-lymphocyte CD3 receptor and immunonegative to B-lymphocyte CD79a receptor. The morphology and distribution of neoplastic T-lymphocytes within the spleen, liver, peripheral blood, and bone marrow was most consistent with chronic T-lymphocytic leukemia. Treatment with chlorambucil and prednisone effectively decreased the lymphocyte count, but was associated with thrombocytopenia, which resolved after chlorambucil treatment was temporarily discontinued. Chemotherapy was resumed with a single dose of l-asparaginase, followed by a lower dosage of chlorambucil and continued prednisone. Two years after initial diagnosis, the hyena developed a hemoabdomen and was euthanized. Neoplastic T-lymphocytes were present in spleen, liver, visceral and peripheral lymph nodes, lungs, heart, kidney, adrenal glands, mesentery, intestines, pancreas, brain, and bone marrow.

Cora L. Singleton "DIAGNOSIS AND TREATMENT OF CHRONIC T-LYMPHOCYTIC LEUKEMIA IN A SPOTTED HYENA (CROCUTA CROCUTA)," Journal of Zoo and Wildlife Medicine 38(3), 488-491, (1 September 2007). https://doi.org/10.1638/1042-7260(2007)38[488:DATOCT]2.0.CO;2
Received: 27 February 2006; Published: 1 September 2007
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