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1 March 2009 The Pharmacokinetics of Single Dose Intramuscular Amoxicillin Trihydrate in Tammar Wallabies (Macropus eugenii)
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Abstract

Five tammar wallabies (Macropus eugenii) were injected intramuscularly with 10 mg/kg amoxicillin trihydrate. Serial blood samples were collected through to 26 hr postinjection. Plasma amoxicillin concentrations were measured using high-performance liquid chromatography. Pharmacokinetic parameters were estimated using noncompartmental analysis. The terminal half-life (1.77 ± 0.40 hr) was comparable to that previously reported in domestic small ruminants. Without intravenous kinetic data, it is unclear whether the terminal phase is elimination- or absorption-dependent; both scenarios have been reported in domestic species. Plasma concentrations of amoxicillin remained above a reported minimum inhibitory concentration (MIC) breakpoint for staphylococci and streptococci for at least 8 hr; the MIC breakpoint for enterobacteria and enterococci was never attained.

David J. McLelland, Brian G. Rich, and Peter H. Holz "The Pharmacokinetics of Single Dose Intramuscular Amoxicillin Trihydrate in Tammar Wallabies (Macropus eugenii)," Journal of Zoo and Wildlife Medicine 40(1), 113-116, (1 March 2009). https://doi.org/10.1638/2008-0104.1
Received: 26 June 2008; Published: 1 March 2009
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