Fatal Fulminant Hepatitis in a Chimpanzee (Pan troglodytes) Receiving Cyproterone Acetate

Wendi D. Roe; Katja Geschke; Chris Pease

doi:10.1638/2009-0031.1

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Wendi D. Roe, Katja Geschke, Chris Pease^*

^*From the Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, PN4442, New Zealand (Roe); the Wellington Zoo Trust, 200 Daniell Street, Newtown, WN6021, New Zealand (Geschke); and Aotea Pathology, CMC Building, 89 Courtenay Place, Te Aro, WN6011, New Zealand (Pease). Correspondence should be directed to Dr. Roe (w.d.roe@massey.ac.nz).

Abstract

Cyproterone acetate is a steroidal anti-androgen that has been used in human medicine for contraceptive purposes as well as treatment of medical conditions responsive to suppression of testosterone production. While serious side effects are considered to be rare, sporadic cases of severe hepatitis have been reported, including several fatal cases. This report describes a case of fatal fulminant hepatitis in one of four male chimpanzees (Pan troglodytes) that were undergoing trial treatment with cyproterone acetate to decrease inter-male aggression.

Citation Download Citation

Wendi D. Roe, Katja Geschke, and Chris Pease "Fatal Fulminant Hepatitis in a Chimpanzee (Pan troglodytes) Receiving Cyproterone Acetate," Journal of Zoo and Wildlife Medicine 40(4), 799-802, (1 December 2009). https://doi.org/10.1638/2009-0031.1

Received: 24 February 2009; Published: 1 December 2009

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