An adult male common genet (Genetta genetta) was examined for an onset of severe dyspnea. Physical examination findings included tachypnea and increased inspiratory sounds. Survey radiographs showed consolidation of both lung lobes, and a bronchoalveolar lavage sample contained cholesterol crystals. The genet was treated with a glucocorticoid but died overnight. Gross necropsy findings included consolidated lungs, multiple pale foci in the heart, and an atrophic right kidney. The histologic diagnosis was metastatic adenocarcinoma with associated endogenous lipid pneumonia.