The histologic and immunohistochemical features of a case of mammary gland carcinoma are described in a 14-yr-old female tiger (Panthera tigris). Immunoreactivity to estrogen receptor (ER), progesterone receptor (PR), tumoral protein 53 (p53), vascular endothelial growth factor (VEGF), human epidermal growth factor receptor 2 (HER-2), and cyclooxigenase-2 (COX-2) was investigated. Neoplastic cells were negative for ER, PR, and p53 but showed positivity for VEGF, HER-2, and COX-2, both in the primary and the metastatic lesions. Histopathologic findings and immunohistochemistry results suggested that the malignant behavior of the reported case could be comparable with some aggressive cat mammary carcinomas.
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1 March 2011
Mammary Carcinoma in a Tiger (Panthera tigris): Morphological and Immunohistochemical Study
Riccardo Finotello,
Lorenzo Ressel,
Ranieri Verin,
Simonetta Di Lollo,
Gianna Baroni,
Renato Piccinini,
Alessandro Poli
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immunohistochemistry
mammary carcinoma
tiger
wildlife
zoo animals
