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20 September 2012 ANTINOCICEPTIVE EFFICACY OF BUPRENORPHINE AND HYDROMORPHONE IN RED-EARED SLIDER TURTLES (TRACHEMYS SCRIPTA ELEGANS)
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Abstract

Despite the frequent clinical use of buprenorphine in reptiles, its antinociceptive efficacy is not known. In a randomized, complete cross-over study, the antinociceptive efficacy of buprenorphine (0.2 mg/kg s.c.) was compared with hydromorphone (0.5 mg/kg s.c.), and saline (0.9% s.c. equivalent volume) in 11 healthy red-eared slider turtles (Trachemys scripta elegans). Additionally, buprenorphine at 0.1 and 1 mg/kg was compared with saline in six turtles. Hindlimb withdrawal latencies were measured after exposure to a focal, thermal noxious stimulus before and between 3 hr and up to 96 hr after drug administration. Buprenorphine did not significantly increase hindlimb withdrawal latencies at any time point compared with saline. In contrast, hydromorphone administration at 0.5 mg/kg significantly increased hindlimb withdrawal latencies for up to 24 hr. These results show that hydromorphone, but not buprenorphine, provides thermal antinociception in red-eared slider turtles.

American Association of Zoo Veterinarians
Christoph Mans, Lesanna L. Lahner, Bridget B. Baker, Stephen M. Johnson, and Kurt K. Sladky "ANTINOCICEPTIVE EFFICACY OF BUPRENORPHINE AND HYDROMORPHONE IN RED-EARED SLIDER TURTLES (TRACHEMYS SCRIPTA ELEGANS)," Journal of Zoo and Wildlife Medicine 43(3), 662-665, (20 September 2012). https://doi.org/10.1638/2011-0260R.1
Received: 22 November 2011; Published: 20 September 2012
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