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1 December 2016 CEREBELLAR AND MESENCEPHALON NEOPLASIA IN A NILE HIPOPPOTAMUS (HIPPOPOTAMUS AMPHIBIOUS)
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Abstract

A 52-yr-old female Nile hippopotamus (Hippopotamus amphibious) was presented for acute onset anorexia, depression, lethargy, instability, and weakness in the pelvic limbs. Clinical signs were rapidly progressive, despite empiric therapy with anti-inflammatory medications, resulting in the death of the animal. Gross necropsy evaluation revealed two tan, firm masses in the cerebellum and mesencephalon and a single mass in the right cranial adrenal gland. All three masses had a similar histologic morphology, and immunohistochemical investigation confirmed the general diagnosis of an adenocarcinoma, but the exact cell of origin remains unclear. In addition, there was evidence of neuroendocrine differentiation in the adrenal gland and not in the brain. These findings suggest either two distinct neoplastic populations or a metastasizing adenocarcinoma with focal endocrine differentiation. In dogs, anal sac and clitoral adenocarcinomas have been reported to undergo focal endocrine differentiation, and both can cause widespread metastasis while the primary lesion can be small. A small neoplasm of these glands may have been missed on gross examination.

Copyright 2016 by American Association of Zoo Veterinarians
Francesca Schiaffino, Samantha J. Sander, Marcia E. Pereira Bacares, Katie J. Barnes, Matti Kiupel, Timothy Walsh, and Suzan Murray "CEREBELLAR AND MESENCEPHALON NEOPLASIA IN A NILE HIPOPPOTAMUS (HIPPOPOTAMUS AMPHIBIOUS)," Journal of Zoo and Wildlife Medicine 47(4), 1093-1096, (1 December 2016). https://doi.org/10.1638/2015-0256.1
Received: 6 November 2015; Published: 1 December 2016
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