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1 December 2017 PHARMACOKINETIC PARAMETERS OF CEFOVECIN SODIUM (CONVENIA) IN CAPTIVE TIGERS (PANTHERA TIGRIS)
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Abstract

A single 8 mg/kg dose of Cefovecin (Convenia®) was administered intramuscularly in the hindlimb of eight anesthetized captive tigers (Panthera tigris) and serial blood samples were collected over the next 56 days to determine pharmacokinetic characteristics. High-performance liquid chromatography was utilized to determine plasma levels, and demonstrated a mean terminal half-life of 227.8 ± 29.3 hr. Cefovecin, >1 μg/ml, was detected in plasma levels up to 56 days postinjection. Protein binding of tiger plasma for cefovecin was 98%. The long duration of therapeutic plasma concentrations and lack of adverse effects make cefovecin a useful antimicrobial drug for tigers.

Copyright 2017 by American Association of Zoo Veterinarians
Andrew C. Cushing, Edward C. Ramsay, James Steeil, and Sherry Cox "PHARMACOKINETIC PARAMETERS OF CEFOVECIN SODIUM (CONVENIA) IN CAPTIVE TIGERS (PANTHERA TIGRIS)," Journal of Zoo and Wildlife Medicine 48(4), 1188-1192, (1 December 2017). https://doi.org/10.1638/2017-0083.1
Accepted: 1 August 2017; Published: 1 December 2017
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