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1 March 2015 Larvicidal Activity of Naturally Occurring Naphthalenedione and its Structurally Related Analogs Against Three Mosquito Species
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Abstract

The objective of this study was to determine the larvicidal activity of an active compound isolated from Cercis chinensis heartwood and its structurally related analogs against 4th-stage Aedes aegypti, Culex pipiens pallens, and Ae. togoi. The larvicidal compound of C. chinensis was isolated with the use of various chromatographic techniques and identified as analogs of 1,4-naphthalenedione. Based on the median lethal concentration (LC50) values of commercially procured analogs against Ae. aegypti larvae, the most toxic analog was 2-bromo-1,4-naphthalenedione (1.19 µg/ml); followed by 5-hydroxy-1,4-naphthalenedione (1.72 µg/ml); 2-methyl-1,4-naphthalenedione (9.12 µg/ml); 2-hydroxy-1,4-naphthalenedione (10.76 µg/ml); and 2-methoxy-1,4-naphthalenedione (12.50 µg/ml). Similar results were observed against Cx. p. pallens and Ae. togoi larvae with 1,4-naphthalenedione analogs. These results also showed that 1,4-naphthalenedione analogs were less toxic than the organophosphate pirimiphos-methyl. Nonetheless, naturally occurring C. chinensis–derived materials and 1,4-naphthalenedione analogs have potential for development as mosquito larvicidal agents.

2015 by The American Mosquito Control Association, Inc.
Ju-Hyun Jeon, Min-Gi Kim, and Hoi-Seon Lee "Larvicidal Activity of Naturally Occurring Naphthalenedione and its Structurally Related Analogs Against Three Mosquito Species," Journal of the American Mosquito Control Association 31(1), (1 March 2015). https://doi.org/10.2987/14-6438.1
Published: 1 March 2015
JOURNAL ARTICLE
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