Land use and land cover (LULC) changes that occurred during 1992–2011 in Sagarmatha National Park, a United Nations Educational, Scientific, and Cultural Organization World Heritage Site in the Himalayas of eastern Nepal, were evaluated using multitemporal satellite imagery in combination with land use data and sociological information gathered from semistructured interviews and workshops. We asked study participants about LULC changes, the causes of each change, and the likely duration of its effects, and used this information to produce high-resolution maps of local perceptions of LULC change. Satellite image analysis revealed that above 6000 m there has been a decrease in the area covered by snow and ice and a consequent expansion of glacial lakes and areas covered by rock and soil. Between 3000 and 6000 m, forest and farmland are decreasing, and areas under grazing, settlement, and shrubland are increasing. Such LULC changes within the protected area clearly indicate the prevailing danger of land degradation. Results from the interviews and workshops suggest that people tended to detect LULC change that was acute and direct, but were less aware of slower changes that could be identified by satellite imagery analysis. Most study participants said that land use changes were a result of rapid economic development and the consequent pressure on natural resources, especially in the tourism industry and especially below 6000 m elevation, as well as limitations to protected area management and a period of civil war. Human influence coupled with climate change may explain the changes at higher elevations, whereas anthropogenic activities are solely responsible in lower areas. Although global factors cannot be mitigated locally, many of the local drivers of LULC change could be addressed with improved management practices that aid local conservation and development in this high mountain ecosystem. A broader interdisciplinary approach to LULC change should include a mix of satellite image analysis and local observations.