Ilex guaramacalensis Cuello & Aymard (Aquifoliaceae), a new species from the Andean forests and páramos of Guaramacal massif in Venezuela, is described and illustrated, and its morphological relationships with allied species are discussed. Ilex guaramacalensis is morphologically similar to I. kunthiana Triana from the high mountains of Costa Rica and Panama, the Coastal Cordillera, and the Andes of Venezuela to Peru, but the new species differs by the shape of its young branchlets, leaves, pedicels, and petals; the higher number of secondary veins; the shorter inflorescences; and the 4-merous flowers. Information about the floristic composition and habitat characteristics for the new species is also provided.
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