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1 February 2000 Determinants of the Apoptotic Response to Lysosomal Photodamage
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Abstract

Studies with mouse leukemia L1210 cells revealed that selective lysosomal photodamage caused by any of three photosensitizing agents was followed by a gradual loss of the mitochondrial membrane potential (ΔΨm), release of cytochrome c into the cytosol, increased DEVDase activity (a measure of levels of caspase-3) and a limited apoptotic response. Similar effects were observed in the murine hepatoma 1c1c7 cell line. Immunofluorescence techniques employing 1c1c7 cells demonstrated the immediate release of the lysosomal enzyme cathepsin B following lysosomal photodamage. These studies suggest that the cytotoxic effects of lysosomal photodamage are initiated by released lysosomal proteases that either directly and/or indirectly activate caspases as a consequence of the induction of mitochondrial damage.

David Kessel, Yu Luo, Patricia Mathieu, and John J. Reiners, Jr "Determinants of the Apoptotic Response to Lysosomal Photodamage," Photochemistry and Photobiology 71(2), 196-200, (1 February 2000). https://doi.org/10.1562/0031-8655(2000)071<0196:DOTART>2.0.CO;2
Received: 13 August 1999; Accepted: 1 November 1999; Published: 1 February 2000
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