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1 January 2003 Changes in DNA Flexibility after Irradiation with γ Rays and Neutrons Studied with the Perturbed Angular Correlation Method
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Abstract

Tsoulou, E., Kalfas, C. A. and Sideris, E. G. Changes in DNA Flexibility after Irradiation with γ Rays and Neutrons Studied with the Perturbed Angular Correlation Method. Radiat. Res. 159, 33–39 (2003).

Neutron and γ irradiation of buffered solutions of calf thymus DNA resulted in changes in the dynamics of the macromolecule. In the low-dose region (0.8–10 cGy of 239Pu-Be neutrons and 0.34–3 Gy of 60Co γ rays), the flexibility of DNA decreased as indicated by slower rotation of the molecules. Neutrons appeared to be approximately 35 times more effective than 60Co γ rays. The rotational correlation time, τC, was measured using the perturbed angular correlation (PAC) method. Its variation appears to follow a linear-exponential behavior. An attempt is made to formulate this behavior as a function of the energy deposited on the macromolecule (radiation dose), the average threshold energy (dose) required to form new lesions, and the available population of intact DNA sites.

E. Tsoulou, C. A. Kalfas, and E. G. Sideris "Changes in DNA Flexibility after Irradiation with γ Rays and Neutrons Studied with the Perturbed Angular Correlation Method," Radiation Research 159(1), 33-39, (1 January 2003). https://doi.org/10.1667/0033-7587(2003)159[0033:CIDFAI]2.0.CO;2
Received: 26 September 2001; Accepted: 1 September 2002; Published: 1 January 2003
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