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1 October 2003 Relative Biological Effectiveness and Tolerance Dose of Fission Neutrons in Canine Skin for a Potential Combination of Neutron Capture Therapy and Fast-Neutron Therapy
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Abstract

Kadosawa, T., Ohashi, F., Nishimura, R., Sasaki, N., Saito, I., Wakabayashi, H. and Takeuchi, A. Relative Biological Effectiveness and Tolerance Dose of Fission Neutrons in Canine Skin for a Potential Combination of Neutron Capture Therapy and Fast-Neutron Therapy. Radiat. Res. 160, 436–442 (2003).

To investigate the potential efficacy of fission neutrons from a fast-neutron reactor for the treatment of radioresistant tumors, the relative biological effectiveness (RBE) and tolerance dose of fission neutrons in canine skin were determined. The forelimbs of 34 healthy mongrel dogs received a single dose of fission neutrons (5.6, 6.8, 8.2, 9.6 or 11 Gy) or 137Cs γ rays (10, 15, 20, 25 or 30 Gy). Based on observations of radiodermatitis for each radiation, the single-fraction RBE of fission neutrons in the sixth month was calculated as approximately 3. The tolerance doses of fission neutrons and γ rays, defined as the highest doses giving no moist desquamation on the irradiated skin in the recovery phase, were estimated as 7.6 Gy and 20 Gy, respectively. The tolerance dose of 7.6 Gy of fission neutrons included 5.0 Gy of fast neutrons possessing high anti-tumor effects and 1.4 × 1012 n/cm2 of thermal neutrons, which could be applicable to neutron capture therapy (NCT). The combination of fast-neutron therapy and NCT using a fast-neutron reactor might be useful for the treatment of radioresistant tumors.

Tsuyoshi Kadosawa, Fumihito Ohashi, Ryohei Nishimura, Nobuo Sasaki, Isao Saito, Hiroaki Wakabayashi, and Akira Takeuchi "Relative Biological Effectiveness and Tolerance Dose of Fission Neutrons in Canine Skin for a Potential Combination of Neutron Capture Therapy and Fast-Neutron Therapy," Radiation Research 160(4), 436-442, (1 October 2003). https://doi.org/10.1667/RR3056
Received: 7 February 2003; Accepted: 1 April 2003; Published: 1 October 2003
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