Prolongation of Life Span Associated with Immunological Modification by Chronic Low-Dose-Rate Irradiation in MRL-lpr/lpr Mice

Yasuhiro Ina; Kazuo Sakai

doi:10.1667/RR3120

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1 February 2004 Prolongation of Life Span Associated with Immunological Modification by Chronic Low-Dose-Rate Irradiation in MRL-lpr/lpr Mice

Yasuhiro Ina, Kazuo Sakai

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Radiation Research, 161(2):168-173 (2004). https://doi.org/10.1667/RR3120

Abstract

Ina, Y. and Sakai, K. Prolongation of Life Span Associated with Immunological Modification by Chronic Low-Dose-Rate Irradiation in MRL-lpr/lpr Mice. Radiat. Res. 161, 168–173 (2004).

Chronic low-dose-rate γ irradiation at 0.35 or 1.2 mGy/h prolonged the life span of MRL-lpr/lpr mice carrying a deletion in the apoptosis-regulating Fas gene that markedly shortens life due to severe autoimmune disease. Immunological modifications as indicated by a significant increase of CD8 T cells and a significant decrease of CD3 CD45R/B220 as well as CD45R/B220 CD40 cells were found in parallel with amelioration of total-body lymphadenopathy, splenomegaly, proteinuria, and kidney and brain syndromes.

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Yasuhiro Ina and Kazuo Sakai "Prolongation of Life Span Associated with Immunological Modification by Chronic Low-Dose-Rate Irradiation in MRL-lpr/lpr Mice," Radiation Research 161(2), 168-173, (1 February 2004). https://doi.org/10.1667/RR3120

Received: 14 May 2003; Accepted: 1 September 2003; Published: 1 February 2004

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