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7 July 2016 Ionizing Radiation-Induced Endothelial Cell Senescence and Cardiovascular Diseases
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Abstract

Exposure to ionizing radiation induces not only apoptosis but also senescence. While the role of endothelial cell apoptosis in mediating radiation-induced acute tissue injury has been extensively studied, little is known about the role of endothelial cell senescence in the pathogenesis of radiation-induced late effects. Senescent endothelial cells exhibit decreased production of nitric oxide and expression of thrombomodulin, increased expression of adhesion molecules, elevated production of reactive oxygen species and inflammatory cytokines and an inability to proliferate and form capillary-like structures in vitro. These findings suggest that endothelial cell senescence can lead to endothelial dysfunction by dysregulation of vasodilation and hemostasis, induction of oxidative stress and inflammation and inhibition of angiogenesis, which can potentially contribute to radiation-induced late effects such as cardiovascular diseases (CVDs). In this article, we discuss the mechanisms by which radiation induces endothelial cell senescence, the roles of endothelial cell senescence in radiation-induced CVDs and potential strategies to prevent, mitigate and treat radiation-induced CVDs by targeting senescent endothelial cells.

Yingying Wang, Marjan Boerma, and Daohong Zhou "Ionizing Radiation-Induced Endothelial Cell Senescence and Cardiovascular Diseases," Radiation Research 186(2), 153-161, (7 July 2016). https://doi.org/10.1667/RR14445.1
Received: 3 March 2016; Accepted: 24 May 2016; Published: 7 July 2016
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