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22 March 2019 Cardiac and Renal Delayed Effects of Acute Radiation Exposure: Organ Differences in Vasculopathy, Inflammation, Senescence and Oxidative Balance
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Abstract

We have previously shown significant pathology in the heart and kidney of murine hematopoietic-acute radiation syndrome (H-ARS) survivors of 8.7–9.0 Gy total-body irradiation (TBI). The goal of this study was to determine temporal relationships in the development of vasculopathy and the progression of renal and cardiovascular delayed effects of acute radiation exposure (DEARE) at TBI doses less than 9 Gy and to elucidate the potential roles of senescence, inflammation and oxidative stress. Our results show significant loss of endothelial cells in coronary arteries by 4 months post-TBI (8.53 or 8.72 Gy of gamma radiation). This loss precedes renal dysfunction and interstitial fibrosis and progresses to abnormalities in the arterial media and adventitia and loss of coronary arterioles. Major differences in radiation-induced pathobiology exist between the heart and kidney in terms of vasculopathy progression and also in indices of inflammation, senescence and oxidative imbalance. The results of this work suggest a need for different medical countermeasures for multiple targets in different organs and at various times after acute radiation injury to prevent the progression of DEARE.

Unthank, J. L, Ortiz, M., Trivedi, H., Pelus, L. M., Sampson, C. H., Sellamuthu, R., Fisher, A., Chua, H. L., Plett, A., Orschell, C. M., Cohen, E. P. and Miller, S. J. Cardiac and Renal Delayed Effects of Acute Radiation Exposure: Organ Differences in Vasculopathy, Inflammation, Senescence and Oxidative Balance. Radiat. Res. 191, 383–397 (2019).

©2019 by Radiation Research Society. All rights of reproduction in any form reserved.
Joseph L. Unthank, Miguel Ortiz, Hina Trivedi, Louis M. Pelus, Carol H. Sampson, Rajendran Sellamuthu, Alexa Fisher, Hui Lin Chua, Artur Plett, Christie M. Orschell, Eric P. Cohen, and Steven J. Miller "Cardiac and Renal Delayed Effects of Acute Radiation Exposure: Organ Differences in Vasculopathy, Inflammation, Senescence and Oxidative Balance," Radiation Research 191(5), 383-397, (22 March 2019). https://doi.org/10.1667/RR15130.1
Received: 7 May 2018; Accepted: 26 February 2019; Published: 22 March 2019
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