Malpighia mexicana, or red nanche, is a plant with edible fruits, used on crafts and medicine, as well as for the establishment of living fences. The objective of this work was to catalog the parasitoids associated with Anthonomus sisyphus Clark (Coleoptera: Curculionidae) in the fruit of M. mexicana in the central valleys of Oaxaca, México. The sampling sites were located in San Lorenzo Cacaotepec and the Ethnobotanical Garden of Santo Domingo. From 2005 to 2007, mature red nanche fruits were collected weekly to determine the emergency of the parasitoids. The fruits were weighed, counted and placed in trays. The greatest infestation was found in San Lorenzo Cacaotepec with 1.16 to 1.44 weevils per fruit while in theEthnobotanical Garden were 0.74 to 1.18 weevils per fruit. Seven different species of parasitoids belonging to the families Braconidae, Pteromalidae, and Eupelmidae were found associated with A. sisyphus. The most abundant species were Triaspis eugenii, Diospilus sp., and Bracon sp. The Ethnobotanical Garden was the site with the greatest abundance of species of parasitoids and presented the highest level of parasitism. The species with the highest proportion of males were Bracon sp. in 2005 and 2007 and T. eugenii in 2006.