The section Multiflorae of Bomarea subgenus Bomarea s.str. is revised. Seventy-nine species of Bomarea s.str. occur from Mexico (23°N) to Chile (40°S) on the western side of the Andes and on the eastern side to 28°S in Argentina. The 33 species of section Multiflorae can be found from 19°N to 18°S. North of Honduras and south of northern Peru they only grow on the eastern slopes of the American Cordilleras. Their distribution is nearly congruent with the distribution of cloud forests. Different species occur from 1500 m to 4500 m; they grow mostly twining, sometimes suberect to erect. They can be found in the cloud forests, the puna, and páramo. This section includes hummingbird pollinated and insect pollinated species. To date, 75 binomials are validly published, and, in this publication, 33 species are accepted. The distribution, morphology, variability, and ecology of the Multiflorae species are discussed.