Taxonomic studies in Heuchera from the southern Intermountain Region in Arizona and New Mexico, U. S. A. have revealed two new species from Heuchera section Heuchera: Heuchera soltisii (Heuchera subsect. Parvifoliae) and Heuchera inconstans (H. subsect. Novomexicanae). Heuchera soltisii is segregated from H. parvifolia on the basis of a larger white hypanthium and variegated leaves; H. inconstans is distinguished from H. novomexicana by its green flowers, the frequent occurrence (up to one-third) of 6-merous flowers, and its specificity to sandstone. Taxonomic studies from new material have also brought to light additional morphological characters that delimit taxa in this group. Confusion regarding the limits of H. glomerulata is addressed through an emended description based on anther thecae and floral color. A key for the species of Heuchera sect. Heuchera is also provided.