Inquiry, discovery, and technology are key pillars in improving science education. We present an inquiry-based lab project using the worldwide symbiosis between the bacterium Wolbachia and invertebrates. This endeavor, called “Discover the Microbes Within! The Wolbachia Project,” has the following goals: (1) involve students in grade 7 through college in a nationwide effort to collect new genetic information on Wolbachia; (2) provide curriculum, protocols, and training to enhance teachers' ability to lead students through the project; and (3) increase students' understanding of biodiversity, evolution, symbiosis, cell biology, molecular biology, and bioinformatics.
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