Fissidens minutifrons is described and illustrated from Ecuador. The species belongs to subgenus Pachyfissidens section Pachyfissidens and is similar to F. grandifrons and F. geijskesii. The distinctive features of the species include: closely imbricate, narrowly lanceolate, elimbate leaves; taxifolius type costae; smooth laminal cells that vary from 2–4-stratose near the costae to 1–2-stratose at the margins in dorsal and ventral laminae, and 1–2-stratose from costae to margins in the vaginant laminae; laminal cells differing greatly in size, decreasing in size from costae to margins, juxtacostal cells and several inner rows larger and quadrate to oblong, several rows of outer (marginal) cells smaller and quadrate to hexagonal, the areas of larger inner cells and smaller outer cells greatest in the vaginant laminae.