A new fossil weevil species of the cossonine genus Caulophilus Wollaston, Caulophilus ayotzinapa Barrios-Izás, new species, from the late Oligocene to middle Miocene amber of Totolapa, Chiapas, Mexico, is described. This represents the first record of the genus from Mexican amber. Diagnostic characters are the subquadrate shape of the pronotum, the lesser distance between eyes in dorsal view, the shallow seriate-punctate pattern of striae, interstices 8 and 9 costate, and the shape of the basal half of the tibiae widening apicad from the base to the middle of the tibiae.