The taxonomic status of all species of Santinezia Roewer 1923 is defined, and a catalogue is provided. Santinezia lucifer, S. gracilis, S. onorei (all from Ecuador), S. furva (from Colombia and Venezuela) and S. hermosa (from Peru) are newly described. Santinezia biordi González-Sponga 1991 is newly considered as a junior subjective synonym of S. serratotibialis Roewer 1932. Santinezia albilineata Roewer 1932, Goniosoma pavani Muñoz-Cuevas 1972, S. benedictoi Soares & Avram 1981, S. decui Avram 1987, S. orghidani Avram 1987 and S. francourbani Avram 1987 are newly considered as junior subjective synonyms of Inezia curvipes Roewer 1916. Nieblia Roewer 1925, Chondrocranaus Roewer 1932, Macuchicola Mello-Leitão 1943 and Carvalholeptes H. Soares 1970 are newly considered as junior subjective synonyms of Santinezia. Nieblia camposi Mello-Leitão 1942 is transferred to Spinicranaus Roewer 1913. Santinezia albimedialis Goodnight & Goodnight 1943 is transferred to Phareicranaus Roewer 1913. Nieblia magna Roewer 1932 is transferred to Neocranaus Roewer 1913. Santinezia micheneri Goodnight & Goodnight 1947 is newly considered as a junior subjective synonym of Phareicranaus ornatus Roewer 1932. A character survey is done including newly discovered characters of genital morphology, patterns of colored marks of dorsal scutum and armature of male leg IV. A phylogenetic analysis of the species of the genus for which males are known is provided allowing the definition of three new species groups. Comparative descriptions are given of the penial morphology of one species of Ventrivomer, one species of Phareicranaus and eight species of Santinezia. Distribution maps for all species of Santinezia are given. The type locality of S. serratotibialis Roewer 1932 is corrected from Trinidad (Bolivia) to Trinidad (Trinidad & Tobago).