Isoscella, gen. n., is newly described in the family Mimallonidae with Isoscella ventana, comb. n. (Dognin, 1897), as its type species, transferring this taxon from Psychocampa Grote & Robinson, 1866. We describe and figure the female of I. ventana for the first time. Our investigation into this species resulted in the recognition of the following new species: I. ecuadoriana, sp. n., from Ecuador, I. leva, sp. n., from Peru and Bolivia, I. peigleri, sp. n., from Colombia and Ecuador, and I. andina, sp. n., from Ecuador and Peru. Both sexes of all species are figured, along with their genitalia. Finally, we discuss the potential close relatives of Isoscella.
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