Two species of Manfreda Salisbury (Agavaceae) endemic to the Mexican Yucatan Peninsula are proposed as new. The new species, Manfreda paniculata L. Hernández, R. Orellana & Carnevali and M. petskinil R. Orellana, L. Hernández & Carnevali are characterized by the presence of long-lasting leaves, paniculate inflorescences, and flowers subtended by a single bracteole—the latter a unique character found within the family Agavaceae and probably within the order Asparagales. Manfreda paniculata is similar to M. sileri, differing from it by the presence of a stem, bulbils, leaves fleshier and more rigid, larger marginal teeth, with long flexible spine-like tip, pedicellated flowers, and shorter floral tube. Manfreda petskinil has been annotated in some herbaria as M. scabra, but the new species is similar to M. variegata, from which it differs by the presence of minutely pubescent and denticulate leaves, ascendant flowers, filament insertion at the mouth of the tube, and a thin style. However, both new species are most closely related to each other than any other species in the genus. Manfreda petskinil is acaulescent with narrower, linear-lanceolate leaves, finely serrulate margins and smaller than M. paniculata.