Three new species are described and illustrated: Ardisia manitzii from the Isla de la Juventud (western Cuba), related with Ardisia mogotensis (another western Cuban endemic), Myrsine pipolyi from Topes de Collantes (central Cuba, prov. Sancti Spíritus) and Myrsine bissei from the Moa area (eastern Cuba, prov. Holguín). The flora of Cuba now includes seven species of Ardisia and six (one previously unrecorded) of Myrsine.