The Cuban representatives of Theophrastaceae are grouped in three genera: Neomezia, endemic of Cuba, Jacquinia s.str., found mainly in the Caribbean, and Bonellia, distributed in the Greater Antilles, Mesoamerica and NE South America. As a result of a taxonomic revision of this family for the Flora de la República de Cuba five new species are described and seven new combinations are published in Cuban Jacquinia and Bonellia.