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1 April 1997 Activin A Inhibits Differentiation of Chick Myogenic Cells In Vitro
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We investigated the effect of activin A on the In Vitro differentiation of primary myogenic cells isolated from chick embryonic breast muscle. As judged by the morphology of the cells and accumulation of creatine kinase, activin A inhibited myogenesis in a dose-dependent manner. The inhibitory activity was reversibly suppressed by follistatin. Activin A also inhibited the expression of MyoD1. Our data also suggest that the inhibitory activity of activin A is exerted neither on proliferation of myoblasts or the growth of myotubes, but rather an early phase of differentiation following the withdrawal from cell cycle. A comparison of actions of activin A and TGF-β suggests that points of action is similar.

Masataka Shiozuka, Takashi Momoi, and Ichiro Kimura "Activin A Inhibits Differentiation of Chick Myogenic Cells In Vitro," Zoological Science 14(2), 327-330, (1 April 1997).
Received: 28 December 1996; Accepted: 1 January 1997; Published: 1 April 1997

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