The effects of somatostatin (SRIF) on in vitro avian adrenal steroid secretion have been investigated in the domestic turkey (Meleagris gallopavo) and fowl (Gallus gallus domesticus). SRIF did not affect either basal or ACTH-stimulated aldosterone and corticosterone production by dispersed turkey adrenocortical cells, but it concentration-dependently inhibited the secretory response to angiotensin II (ANG II). It is concluded that in the turkey, like in mammals, SRIF specifically interferes with the intracellular mechanisms transducing the ANG II secretagogue signal. Fowl adrenocortical cells did not display any secretory response to ANG II, and accordingly SRIF did not alter their basal and agonist-stimulated secretory activity.