Morphological and molecular data are used to address the taxonomic status of two uncommon species of opisthobranch molluscs from the Gulf of Mexico. Chromodoris fentoni is a new species closely related to other Atlantic and eastern Pacific congeneric species. It is characterized by having a whitish background color almost completely covered with irregular red pigment. Glossodoris punctilucens Bergh, 1890 is a rare species known from only a handful of specimens. Morphological and molecular data confirm that it is distinct from other similarly colored species from the eastern Atlantic.