Diphenhydramine HCl (DH) and caffeine are commonly detected contaminants in waterways and drinking water nationwide (U.S.A.) and yet little is known of their influence on the development of aquatic molluscs. The antihistamine diphenhydramine blocks the chemical effects of histamine by inhibiting the re-uptake of serotonin (5-HT). Caffeine can influence the regulation of calcium (Ca2 ) and neurotransmitters, such as 5- HT, by inhibiting the re-uptake of adenosine. Serotonin receptor-mediated signaling is key during embryonic development in the freshwater snail Helisoma trivolvis (Say 1816). Embryonic development rates of H. trivolvis depend upon external conditions such as oxygen concentration and temperature. We examine the effects of diphenhydramine (DH) and caffeine on development and reproductive potential of this common aquatic snail. Concentrations of DH at 40.0, 50.0 and 60.0 µM affect the in-capsule embryonic development and hatching rate. Caffeine at 40.0, 50.0 and 60.0 µM show no influence to the hatching rates; however, these caffeine concentrations influence the in-capsule embryonic rotation rate. Eight-month observations of adult H. trivolvis reproductive activities show no influence in number of egg masses deposited when exposed to test concentrations of DH or caffeine.
You have requested a machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Neither BioOne nor the owners and publishers of the content make, and they explicitly disclaim, any express or implied representations or warranties of any kind, including, without limitation, representations and warranties as to the functionality of the translation feature or the accuracy or completeness of the translations.
Translations are not retained in our system. Your use of this feature and the translations is subject to all use restrictions contained in the Terms and Conditions of Use of the BioOne website.