Hemsleya revoluta Q. Luo, X.W. Li & Q.L. Gan sp. nova (Cucurbitaceae) is described and illustrated from Hubei, central China. It has a revolute, yellow-green, globose corolla completely enveloping the calyx and ovary, and smooth seed margins. It somewhat resembles H. ellipsoidea by its globose corolla and ellipsoid fruit, but differs from the latter by having oblong calyx segments, broadly ovate or broadly obovate corolla segments, and smaller seeds with smooth margins.