The Neotropical Prionocyphon is revised. Cyphon obscurus coccinelloides Pic is elevated to a species level and transferred to Prionocyphon. Prionocyphon auritus Champion, P. coccinelloides (Pic), P. major Pic, P. pilicornis Champion, and P. pubescens Pic are redescribed and illustrated. Nine new species are described: Prionocyphon borowieci sp. nov. (Ecuador), P. championi sp. nov. (Guatemala), P. costaricanus sp. nov. (Costa Rica), P. crassicornis sp. nov. (Bolivia), P. inca sp. nov. (Peru), P. lescheni sp. nov. (Ecuador), P. lyra sp. nov. (Brazil), P. meridensis sp. nov. (Venezuela), and P. napoensis sp. nov. (Ecuador). Prionocyphon minutus Pic, and P. vicinus Pic do not belong to Prionocyphon in the present sense. New records of P. coccinuloides Klausnitzer, P. muchei Klausnitzer, and P. samueli Klausnitzer are reported. Notes on morphology of Prionocyphon are provided.