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7 June 2013 Kangaroo gene mapping and sequencing: insights into mammalian genome evolution
Jennifer A. Marshall Graves
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The deep divergence of marsupials and eutherian mammals 160 million years ago provides genetic variation to explore the evolution of DNA sequence, gene arrangement and regulation of gene expression in mammals. Following the pioneering work of Professor Desmond W. Cooper, emerging techniques in cytogenetics and molecular biology have been adapted to characterise the genomes of kangaroos and other marsupials. In particular, genetic and genomic work over four decades has shown that marsupial sex chromosomes differ significantly from the eutherian XY chromosome pair in their size, gene content and activity. These differences can be exploited to deduce how mammalian sex chromosomes, sex determination and epigenetic silencing evolved.

© CSIRO 2013
Jennifer A. Marshall Graves "Kangaroo gene mapping and sequencing: insights into mammalian genome evolution," Australian Journal of Zoology 61(1), 4-12, (7 June 2013).
Received: 7 January 2013; Accepted: 1 April 2013; Published: 7 June 2013
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