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1 September 2004 Identification of a Novel Nephropathogenic Infectious Bronchitis Virus in Israel
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A novel infectious bronchitis variant, designated as IS/885/00, associated with nephritis, was isolated from outbreaks in 23 broiler farms in Israel. The virus was first identified by reverse transcriptase–polymerase chain reaction and showed a distinct restriction fragment length polymorphism pattern from previously described Israeli isolates. Sequence analysis of the S1 gene and the deduced amino acid sequence revealed 97.2% protein similarity to genotype IS/720/99 and 71.6% similarity to the vaccine strain H120, the only strain permitted for use in this country. A database search in GenBank revealed a closely related isolate from Egypt, Egypt/Beni-Seug/01, with 96.6% similarity. Other published nephropathogenic infectious bronchitis virus strains/isolates shared less than 77% similarity with IS/885/00. A vaccine protection test in specific-pathogen-free chicks indicated 91% protection to the trachea and only 25% protection to the kidneys in vaccinated birds challenged with IS/885/00.

R. Meir, E. Rosenblut, S. Perl, N. Kass, G. Ayali, E. Hemsani, and S. Perk "Identification of a Novel Nephropathogenic Infectious Bronchitis Virus in Israel," Avian Diseases 48(3), 635-641, (1 September 2004).
Received: 5 September 2003; Accepted: 1 February 2004; Published: 1 September 2004

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