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1 March 2007 Development of a Reverse Genetics System Enabling theRescue of Recombinant Avian Influenza Virus A/Turkey/England/50-92/91 (H5N1)
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Abstract

We previously described the use of an established reverse genetics system for the generation of recombinant human influenza A viruses from cloned cDNAs. Here, we have assembled a set of plasmids to allow recovery of the avian H5N1 influenza virus A/Turkey/England/50-92/91 entirely from cDNA. This system enables us to introduce mutations or truncations into the cDNAs to create mutant viruses altered specifically in a chosen gene. These mutant viruses can then be used in future pathogenesis studies in chickens and in studies to understand the host range restrictions of avian influenza viruses in humans.

Wendy Howard, Anna Hayman, Angie Lackenby, Alison Whiteley, Brandon Londt, Jill Banks, John McCauley, and Wendy Barclay "Development of a Reverse Genetics System Enabling theRescue of Recombinant Avian Influenza Virus A/Turkey/England/50-92/91 (H5N1)," Avian Diseases 51(s1), 393-395, (1 March 2007). https://doi.org/10.1637/7645-050906R1.1
Received: 8 May 2006; Accepted: 1 August 2006; Published: 1 March 2007
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