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1 September 2009 Selection for Increased Nitric Oxide Production Does Not Increase Resistance to Marek's Disease in a Primary Broiler Breeder Line
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Abstract

Two primary broiler breeder lines, A and B, were examined for their potential to produce nitric oxide (NO) after stimulating splenocytes from 20-day-old embryos with lipopolysaccharide and interferon-γ. Significant differences were found between lines A and B. Overall, line A had a higher response than line B, but line A also had a large degree of variation between individual sire families. Selection for high and low responders within line A resulted in the segregation of high- and low-responder sire families. Offspring from sire families selected for high and low NO responses and from a nonselected control group from line A were challenged with RB-1B Marek's disease (MD) virus to determine whether these differences could be used to select for improved resistance to MD. Virus isolation rates at 6 and 10 days postinfection were not significantly different, but unexpectedly, the MD incidence in the high-responder group was significantly higher than in the other two groups.

Celina Buscaglia, Priscilla H. O'Connell, Keith W. Jarosinski, Igal Pevzner, and Karel A. Schat "Selection for Increased Nitric Oxide Production Does Not Increase Resistance to Marek's Disease in a Primary Broiler Breeder Line," Avian Diseases 53(3), 336-340, (1 September 2009). https://doi.org/10.1637/8536-113008-Reg.1
Received: 2 December 2008; Accepted: 1 March 2008; Published: 1 September 2009
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