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25 February 2022 Clinically Manifesting, Naturally Occurring Fowl Glioma in a Leghorn Chicken in Germany
Brigitte Böhm, Ivana Bilic, Julia Brüggemann, Hayate Nishiura, Kenji Ochiai
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Abstract

Fowl glioma-inducing virus (FGV), a strain of avian leukosis virus (ALV) subgroup A, is the causal agent of fowl glioma characterized by multiple nodular astrocytic growths, gliosis, and lymphocytic encephalitis. Also associated with FGV infection are cases of cerebellar hypoplasia, perineuromas, and nonsuppurative myocarditis. Though fowl glioma has been recognized in several countries, most reports of FGV infection come from Japan. A 9-mo-old brown leghorn from a German farm with nine leghorns was presented to a veterinarian with an impaired general health with torticollis, tremor, and incoordination. Histopathology revealed multifocal nodular astrocytic growths, gliosis, and a lymphoplasmacytic encephalitis. Immunohistochemically, neoplastic astrocytes showed positivity for anti-ALV antibody. FGV was detected in the brain with nested reverse transcription-polymerase chain reaction (RT-PCR) and subsequent sequencing of PCR product. The remaining eight birds were screened for the presence of ALV with real-time RT-PCR. Four leghorns tested positive for exogenous ALV in nested RT-PCR with an identical nucleotide sequence as the leghorn with neurological symptoms. To the authors' knowledge this is the first report of a natural FGV infection in a brown leghorn in Germany with clinical manifestation.

Brigitte Böhm, Ivana Bilic, Julia Brüggemann, Hayate Nishiura, and Kenji Ochiai "Clinically Manifesting, Naturally Occurring Fowl Glioma in a Leghorn Chicken in Germany," Avian Diseases 66(1), 119-123, (25 February 2022). https://doi.org/10.1637/aviandiseases-21-00090
Received: 29 September 2021; Accepted: 2 January 2022; Published: 25 February 2022
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KEYWORDS
ALV
avian leukosis virus
FGV
fowl glioma-inducing virus
histopathology
Nested-PCR
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