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27 April 2022 Porphyrin Accumulation and Biliary Lithiasis Causing Diffusely Black Livers in Broiler Chickens
Veronica Nguyen, Asli Mete, Anibal Armien, Ana P. da Silva, Patrick Montine, Charles Corsiglia, V. M. Sadagopa Ramanujam, Karl E. Anderson, Ruediger Hauck, Rodrigo A. Gallardo
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Abstract

Two 7-wk-old broiler chickens presented with uniformly black livers upon postslaughter examination, while all other organs as well as their carcasses were grossly normal. No clinical signs were reported by the field veterinarian prior to slaughter. Other broiler chickens within the same flock were unaffected. Microscopically, the liver exhibited variably sized, globoid concrements that were dark brown to green-brown and birefringent under polarized light. Ultrastructurally, concrements consisted of radially arranged electron-dense crystal spicules. Concrements were located in hepatocytes, within ecstatic bile canaliculi, or surrounded by small clusters of macrophages. Liquid chromatography assay determined the presence of protoporphyrin IX in the affected liver.

Veronica Nguyen, Asli Mete, Anibal Armien, Ana P. da Silva, Patrick Montine, Charles Corsiglia, V. M. Sadagopa Ramanujam, Karl E. Anderson, Ruediger Hauck, and Rodrigo A. Gallardo "Porphyrin Accumulation and Biliary Lithiasis Causing Diffusely Black Livers in Broiler Chickens," Avian Diseases 66(2), 225-229, (27 April 2022). https://doi.org/10.1637/aviandiseases-D-21-00122
Received: 16 December 2021; Accepted: 10 March 2022; Published: 27 April 2022
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KEYWORDS
black liver
broiler chickens
electron microscopy
pigment deposition
porphyrin
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