Ci Song,^1,* Yan Wang,^2,* Weiqin Li,^3,* Bicheng Hu,⁴ Guohua Chen,⁴ Ping Xia,⁴ Wei Wang,⁴ Chaojun Li, Feiyang Diao,⁵ Zhibin Hu,¹ Xiaoyu Yang,^5,** Bing Yao,^6,** Yun Liu<sup>7,**

1</sup>Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China
²Department of Digestive Endoscopy, The First Affiliated Hospital with Nanjing Medical University, JiangSu Province Hospital, Nanjing, China
³Department of Critical Care Medicine, PLA Key Laboratory of Emergency and Critical Care Research, Jinling Hospital, Nanjing Medical University, Nanjing, China
⁴Wuhan No.1 Hospital, Wuhan, China
⁵Clinical Center of Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
⁶Center for Reproductive Medicine, Jinling Hospital, Nanjing Medical University, Nanjing, China
⁷Schoole of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China.

^*Grant Support: This study was funded in part by the National Key Research and Development Program of China (2018YFC1004200, 2018YFC1004700), the National Natural Science Foundation of China (81903382, 81971374), the Natural Science Foundation of Jiangsu Province (BK20190652), and the China Postdoctoral Science Foundation (General Program, 2019M65190).
^**Correspondence: Xiaoyu Yang, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, 101 Longmian Road, Nanjing 211166, China. Tel: +025-86868440; E-mail: yangxiaoyu@jsph.org.cn; Bing Yao, Center for Reproductive Medicine, Jinling Hospital, Nanjing Medical University, 22 Hankou Road, Nanjing 210002, China. Tel: +025-83593192; E-mail: yaobing@nju.edu.cn; and Yun Liu, School of Biomedical Engineering and Informatics, Nanjing Medical University, 101 Longmian Road, Nanjing 211166, JiangSu, China. Tel: +025-68305258; E-mail: liuyun@njmu.edu.cn