Spermatogonial Dio3 as a potential germ line sensor for thyroid hormone-driven epigenetic inheritance†

Arturo Hernandez

doi:10.1093/biolre/ioab089

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Arturo Hernandez^1,2,3,*

¹Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Health, Scarborough, ME, USA
²Department of Medicine, Tufts University School of Medicine, Boston, MA, USA
³Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, USA

^*Correspondence: Maine Medical Center Research Institute, MaineHealth, Scarborough, ME 04074, USA. Tel: +1-207-396-8139; Fax number: 1-207-396-8110; E-mail: hernaa@mmc.org

Abstract

Thyroid hormone-clearing type 3 deiodinase is located in spermatogonia, where it may serve as a critical modulator of the thyroid hormone exposure of the male germ line and its epigenetic information, with implications for neurodevelopmental and endocrine disorders in subsequent generations.

Citation Download Citation

Arturo Hernandez "Spermatogonial Dio3 as a potential germ line sensor for thyroid hormone-driven epigenetic inheritance^{," Biology of Reproduction 105(3), 613-615, (7 May 2021). https://doi.org/10.1093/biolre/ioab089}

Received: 17 February 2021; Accepted: 17 February 2021; Published: 7 May 2021

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