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28 February 2022 Metabolomic markers of biological fluid in women with reproductive failure: a systematic review of current literatures
Yingying Zhang, Tao Zhang, Ling Wu, Tin Chiu Li, Chi Chiu Wang, Jacqueline Pui Wah Chung
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Abstract

Understanding metabolic changes in reproductive failure, including early miscarriage (EM), recurrent miscarriage (RM), and repeated implantation failure (RIF), may be beneficial to understand the pathophysiology, thus improving pregnancy outcomes. Nine metabolomic profiling studies in women with reproductive failures (4 for EM, 3 for RM, and 2 for RIF) were included for systematic review. In total 78, 75, and 25 significant metabolites were identified and 40, 40, and 34 metabolic pathways were enriched in EM, RM, and RIF, respectively. Among them, 7 and 11 metabolites, and 28 and 28 pathways were shared between EM and RM and between RM and RIF, respectively. Notably, histidine metabolism has the highest impact in EM; phenylalanine, tyrosine, and tryptophan biosynthesis. Ubiquinone and other terpenoid–quinone biosynthesis metabolism have the highest impact factor in RM; alanine, aspartate, and glutamate metabolism have the highest impact factor in RIF. This study not only summarized the common and distinct metabolites and metabolic pathways in different reproductive failures but also summarized limitations of the study designs and methodologies. Hence, further investigations and validations of these metabolites are still urgently needed to understand the underlying metabolic mechanism for the development and treatment of reproductive failures.

Summary sentence Nine metabolomic studies related to reproductive failure were included in this review. Though alterations in metabolites were identified, study designs and methodologies remained controversial. Hence, further studies and validation are necessary.

Graphical Abstract

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© The Author(s) 2022. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
Yingying Zhang, Tao Zhang, Ling Wu, Tin Chiu Li, Chi Chiu Wang, and Jacqueline Pui Wah Chung "Metabolomic markers of biological fluid in women with reproductive failure: a systematic review of current literatures," Biology of Reproduction 106(6), 1049-1058, (28 February 2022). https://doi.org/10.1093/biolre/ioac038
Received: 25 October 2021; Accepted: 10 February 2022; Published: 28 February 2022
JOURNAL ARTICLE
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KEYWORDS
implantation failure
metabolomics
miscarriage
pregnancy
reproductive failure
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